1. Research Methodology

2. Transient Receptor Potential (TRP) Channels and TRPV Family Overview

  2.1 Overview Of The Transient Receptor Potential (TRP) Channel Family

  2.2 Overview Of The TRPV (Vanilloid) Channel Subfamily

  2.3 Introduction To TRPV6: Biology, Physiological Functions and Clinical Significance

3. TRPV6 Biology, Function and Pathophysiology

  3.1 Structural Architecture and Calcium Selectivity Of TRPV6

  3.2 Tissue Distribution, Expression Profile and Cellular Localization Of TRPV6

  3.3 Physiological Roles Of TRPV6 In Calcium Homeostasis and Organ Function

  3.4 TRPV6 Mediated Calcium Signalling In Health and Disease

4. Pharmacological Modulation and Therapeutic Targeting of TRPV6

  4.1 Ligand Mediated Modulation Of TRPV6 Activity

    4.1.1 TRPV6 Antagonism - Mechanisms and Therapeutic Rationale

    4.1.2 TRPV6 Agonism - Mechanisms and Therapeutic Rationale

4.2 Therapeutic Targeting Modalities For TRPV6

    4.2.1 Small Molecule Modulators

    4.2.2 Antibody Based Therapeutic Targeting

    4.2.3 Peptide Based Therapeutic Approaches

    4.2.4 Drug Repurposing Strategies

4.3 Structural Pharmacology and Structure Based Drug Design Of TRPV6

    4.3.1 Pore Targeting and Allosteric Binding Sites In TRPV6

    4.3.2 Lipid Binding, Channel Gating and Allosteric Regulation Of TRPV6

5. TRPV6 Targeted Therapies In Cancer

  5.1 Prostate Cancer

  5.2 Breast Cancer

  5.3 Pancreatic Cancer

  5.4 Ovarian Cancer

  5.5 Esophageal Cancer

6. TRPV6 Targeted Therapies in Non Cancer Disorders

  6.1 Inflammation

  6.2 Calcium Malabsorption Disorders

  6.3 Bone Diseases

  6.4 Kidney Stones

7. Global TRPV6 Targeted Therapies Clinical Trials Overview

  7.1 By Phase

  7.2 By Country

  7.3 By Company

  7.4 By Indication

  7.5 By Priority Status

8. Global TRPV6 Targeted Therapies Clinical Trials Insight By Company, Country, Indication and Phase

  8.1 Preclinical

  8.2 Phase I

  8.3 Phase I/II

  8.4 Phase II/III

9. Global TRPV6 Targeted Therapy Market Scenario

  9.1 Current Market Trends

  9.2 Future Market Opportunities

10. Global TRPV6 Targeted Therapy Market Dynamics

  10.1 Drivers and Opportunities

  10.2 Challenges and Solutions

11. Competitive Landscape

  11.1 Coherent Biopharma

  11.2 Mabqi

  11.3 Soricimed Biopharma

  11.4 UniQuest

Figure 2-1: TRP Channel Family Overview

Figure 2-2: General Structure Of TRP Channels

Figure 2-3: Classification Of Mammalian TRP Channels

Figure 2-4: TRP Channels Activation Mechanisms

Figure 2-5: Functional Classification Of TRPV Subfamily

Figure 2-6: Functional Diversity Of TRPV1–TRPV6

Figure 2-7: Historical Timeline of TRPV6 Research

Figure 2-8: Physiological Roles of TRPV6 in Different Organs

Figure 2-9: Regulation Of TRPV6 Expression

Figure 2-10: Consequences of TRPV6 Dysfunction

Figure 2-11: From Calcium Transporter To Cancer Target

Figure 2-12: Why TRPV6 IS An Attractive Drug Target

Figure 3-1: Structural Basis Of TRPV6 Function

Figure 3-2: Regulation Of TRPV6 By Lipids and Calmodulin

Figure 3-3: Structural Basis Of Pharmacological Inhibition By 2-APB

Figure 3-4: Organ Distribution Of TRPV6 Expression

Figure 3-5: Physiological Functions of TRPV6

Figure 3-6: TRPV6 In Intestinal Calcium Absorption

Figure 3-7: Role Of TRPV6 In Placental Calcium Transport

Figure 3-8: TRPV6 In Male Reproductive Physiology

Figure 3-9: TRPV6 In Bone Homeostasis

Figure 3-10: TRPV6 In Epidermal Differentiation

Figure 3-11: Consequences of TRPV6 Loss- and Gain-of-Function

Figure 4-1: Overview Of TRPV6 Modulation

Figure 4-2: Core Principle Of TRPV6 Antagonism

Figure 4-3: TRPV6-Calcium-NFAT Oncogenic Axis and Its Inhibition

Figure 4-4: Antagonism Effects On Cancer Cell Fate

Figure 4-5: Core Principle Of TRPV6 Agonism

Figure 4-6: Vitamin D–TRPV6 Regulatory Axis and Agonism Concept

Figure 4-7: Safety Window Concept In TRPV6 Agonism

Figure 4-8: Small Molecule TRPV6 Inhibition Strategy

Figure 4-9: Binding Sites Of TRPV6 Small Molecule Inhibitors

Figure 4-10: Mechanism Of TRPV6-Targeting Antibody MQI-201

Figure 4-11: Mechanism Of Antitumor Action Of TRPV6-Targeting Peptides

Figure 4-12: Therapeutic Applications Of TRPV6-Targeting Peptides

Figure 4-13: Concept Of Drug Repurposing For TRPV6 Targeted Cancer Therapy

Figure 4-14: Allosteric Inhibition Of TRPV6 By Econazole

Figure 4-15: Pore blockade vs Allosteric inhibition - Mechanism

Figure 4-16: PIP₂-Dependent Gating Mechanism

Figure 4-17: Lipid Occupancy Vs Drug Displacement Mechanism

Figure 5-1: Crosstalk With Androgen Signaling + SOCE

Figure 5-2: Hormonal Regulation and Drug Modulation Of TRPV6

Figure 5-3: CBP-1008-01 Phase 1 (NCT04740398) Study – Initiation and Completion Year

Figure 5-4: TRPV6 and Chemoresistance

Figure 6-1: Context-Dependent Role Of TRPV6 In Inflammatory Diseases

Figure 6-2: Inflammatory Disease - Therapeutic Strategy Based On TRPV6 Activity

Figure 6-3: Physiological Role Of TRPV6 In Systemic Calcium Homeostasis

Figure 6-4: Calcium Malabsorption Disorders - Therapeutic Strategies Targeting TRPV6

Figure 6-5: Consequences Of TRPV6 Deficiency In Calcium Malabsorption (Secondary Hyperparathyroidism)

Figure 6-6: Central Role Of TRPV6 In Bone Homeostasis

Figure 6-7: Therapeutic Strategies Targeting TRPV6 in Bone Diseases

Figure 6-8: TRPV6 In Calcium Homeostasis and Kidney Stone Formation

Figure 6-9: Mechanisms Of Hypercalciuria Associated With TRPV6

Figure 6-10: Genetic Variants Of TRPV6 and Risk Of Nephrolithiasis

Figure 6-11: Current vs Future Management Of Nephrolithiasis

Figure 7-1: Global – Number Of TRPV6 Inhibitors In Clinical Trials By Phase, 2026

Figure 7-2: Global – Number Of TRPV6 Inhibitors In Clinical Trials By Country, 2026

Figure 7-3: Global – Number Of TRPV6 Inhibitors In Clinical Trials By Company , 2026

Figure 7-4: Global – Number Of TRPV6 Inhibitors In Clinical Trials By Indication, 2026

Figure 7-5: Global – Number Of TRPV6 Inhibitors In Clinical Trials By Priority Status , 2026

Figure 9-1: Global TRPV6 Targeting Therapy - Future Market Opportunities

Figure 10-1: Global TRPV6 Targeting Therapy - Drivers and Opportunities

Figure 10-2: Global TRPV6 Targeting Therapy - Challenges and strategic Solutions

List Of Tables

Table 2-1: Classification and Functions of TRP Channel Subfamilies

Table 2-2: ThermoTRPV v/s Calcium-selective TRPV Channels

Table 2-3: Tissue Distribution Of TRPV Channels

Table 2-4: Physiological Distribution Of TRPV6

Table 2-5: Comparison Of Physiological v/s Pathological TRPV6

Table 3-1: Structural Components Of TRPV6

Table 3-2: Diseases Associated With Altered TRPV6 Function

Table 4-1: Mechanistic Actions Of TRPV6 Antagonists

Table 4-2: Key Conceptual Differences: TRPV6 Agonism vs Antagonism

Table 4-3: Small Molecule TRPV6 Targeting - Advantages

Table 4-4: Peptide Based TRPV6 Inhibitors - Advantages

Table 4-5: Advantages of Drug Repurposing For TRPV6

Table 4-6: Pore block vs Allosteric inhibition In TRPV6

Table 6-1: Inflammatory Disorders - Role Of TRPV6

Table 6-2: Role Of TRPV6 In Calcium Malabsorption Disorders

Table 6-3: Bone Diseases - Therapeutic Potential Of TRPV6

Table 6-4: TRPV6 and Kidney Stone Disease