Global ALK Inhibitors Market Opportunity: > USD 5 Billion
US Dominates Global ALK Inhibitors Market Sales: >30%
Approved ALK Inhibitors: 5 Drugs
Global and Regional ALK Inhibitors Market Sales Insights (2017-2020)
Global and Regional ALK Inhibitors Market Opportunity (2021-2026)
Approved ALK Inhibitors Dosage, Patent, Price and Sales Insights
Global Clinical Trials Insight By Company, Indication and Phase
The progress made by science and technology in last few decades has led to identification of several potential targets which can be utilized in the drug development process. The characterization of anaplastic lymphoma kinase (ALK) gene and their role in the development and progression of ALK positive cancer has transformed the cancer therapeutics market. The extensive research activities by the researchers have led to the development of novel anaplastic lymphoma kinase inhibitors which belongs to the class of tyrosine receptor kinase and are used in the management of cancer.
Till now, multiple anaplastic lymphoma kinase inhibitors have been approved by the regulatory authorities and several others are present in clinical pipeline which are expected to enter the market in next few years. The advent of these drugs in the market has overcome the limitations of conventional therapies such as chemotherapy and radiotherapy. The high target ability and specificity of these inhibitors towards the cancer cells has enhanced the survival rates of cancer patients and also improved the quality of life of patients.
Since the approval of first generation anaplastic lymphoma kinase inhibitor in the management of non small cell lung cancer, researchers have indulge in research activities for the development of next generation inhibitors which can overcome the limitations and can efficiently cross the blood brain barrier for enhanced efficacy. Apart from this, several clinical trials are ongoing to evaluate the efficacy of these drugs in combination with other chemotherapeutic drugs and immune checkpoint inhibitors. The combinational therapy will increase the efficacy of the drug which can better combat the complexity of the cancer.
The global anaplastic lymphoma kinase inhibitor market is going to witness high growth during the forecast period which is mainly attributed to the rise in prevalence of anaplastic lymphoma kinase positive cancers and high research and development activities in this sector. The rates at which conventional therapies are failing will further possess unmet need for the development of novel target therapies which will also drive the growth of the market. In addition to this, the robust clinical pipeline and their increasing application in different cancers will drive the market in coming years.
Despite several advantages of anaplastic lymphoma kinase inhibitors in management of cancer, there are several factors which restrains the growth of market. The resistance to the drugs during 1-2 year of the therapy is one of the limiting factors which will act as a barrier to the market. Moreover, the high cost associated with the drug will also limit the availability of the drug and increases the financial toxicity on the patient and their families.
Currently, US holds the top position in the global market and is expected to maintain its position over the forecast period mainly due to the presence of large pharmaceutical sector which actively invest in research and development activities as well as increasing funding by the government to promote research and development. Apart from this, other regions such Europe, Asia-Pacific and Japan are also expanding their markets to secure their position in the global market. The global anaplastic lymphoma kinase inhibitor market is going to witness high growth rate and is expected to double in next 5 years. Furthermore, the market will be flourished with next generation ALK inhibitors as well as several combintional therapies in wide range of cancers including neuroblastoma, lymphoma and colorectal cancer.
The report “Global Anaplastic Lymphoma Kinase ALK Inhibitors Market and Clinical Trials Insight 2026” includes information about the patent expiration, dosage, price, sales and mechanism of currently approved anaplastic lymphoma kinase inhibitors. In addition to this, several emerging ALK inhibitors along with their clinical trials are also provided in the report.
Introduction to Anaplastic Lymphoma Kinase (ALK) Inhibitors
1.2 History of Development
ALK Inhibitors as Cancer Therapeutics
2.1 Need of ALK Inhibitors in Cancer Therapy
2.2 ALK - Potential Target in Cancer Therapy
2.3 Mechanism of Action
ALK Inhibitors in Lung Cancer
3.1 Role of ALK Inhibitors in Lung Cancer
3.2 On Going Research and Development
ALK Inhibitors in Neuroblastoma
4.1 Role of ALK Inhibitor in Neuroblastoma
4.2 On Going Clinical Research
ALK Inhibitors in Lymphoma
5.1 Role of ALK in Lymphoma
5.2 On Going Clinical Research
ALK Inhibitors in Other Cancers
6.1 ALK Inhibitor in Colorectal Cancer
6.2 ALK in Renal Cell Carcinoma
6.3 ALK Inhibitor in Inflammatory Myofibroblastic Tumor
Crizotinib (Xalkori) - Clinical and Commercial Insight
7.2 Patents and Assignees
7.3 Dosage and Price Analysis
7.4 Sales Analysis
Certinib (Zykadia) - Clinical and Commercial Insight
8.2 Patents and Assignees
8.3 Dosage and Price Analysis
Alectinib (Alecensa) - Clinical and Commercial Insight
9.2 Patents and Assignee
9.3 Dosage and Price Analysis
9.4 Sales Analysis
Brigatinib (Alunbrig) - Clinical and Commercial Insight
10.2 Patent Information
10.3 Dosage and Price Analysis
10.4 Sales Analysis
Lorlatinib (Lorbrena) - Clinical and Commercial Insight
Figure 19-4: Tyrosine Kinase Inhibitor Market by Type (%), 2020
Figure 19-5: Global – ALK Inhibitor Market Opportunity by 15% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
Figure 19-6: Global – ALK Inhibitor Market Opportunity by 20% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
Figure 19-7: Global – ALK Inhibitor Market Opportunity by 25% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
Figure 19-8: Global – ALK Inhibitor Market Opportunity by 25% Tyrosine Kinase Inhibitor Market (US$ Billion), 2021-2026
Figure 19-9: Global – Tagrisso Market Size (US$ Billion), 2017-2020
Figure 19-10: Global – Alectinib Market Size (US$ Billion), 2021-2026
Figure 20-1: ALK Inhibitors Drug Market Favorable Parameters
Figure 20-2: Cancer Incidences by Region (Million), 2020 and 2040
Figure 20-3: Cancer Deaths by Region (Million), 2020 and 2040
Figure 20-4: Alunbrig – Average Cost of Daily, Monthly and Annual Cost of Treatment (US$), March’2021
Figure 20-5: Lorbrena – Average Cost of Daily, Monthly and Annual Cost of Treatment (US$), March’2021
Figure 20-6: Barriers to ALK Inhibitor Drug Market
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