Opioid Dependency to get Treated with SL-BUP and XR-BUP Introduction into the Patients

Release Date: 16-Nov-2020

A group of researchers from the University of Colorado School of Medicine have stated that three individuals who received low dose of buprenorphine as a single extended release treatment against opioid dependency. Among the three patients who were studied, one with had opioid and alcohol use disorders achieved remission from his opioid use disorder (OUD) for 6 years after using sublingual buprenorphine (SL-BUP). After using sublingual buprenorphine (SL-BUP) daily, the patient received single 100 mg subcutaneous injection of extended-release buprenorphine (XR-BUP). There was an improvement in the patients with respect to constipation symptoms and episodes of depersonalization.


Another patient enrolled in the study received 6 mg daily dose of SL-BUP for 14 months and finally she was able to taper down to minimum 2mg dose of the SL-BUP. After receiving SL-BUP, she received XR-BUP injection and following this no withdrawal symptoms no symptoms were reported. Another female enrolled in the study was able to transition to 12 mg SL-BUP for 12 months and after several months she was able to go down to 6mg of SL-BUP. She also received similar injection of XR-BUP post SL-BUP. It was concluded from the study that doses of SL-BUP was able to treat the patients who had opioid dependency for prolonged period of time.

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