Global Bispecific Antibodies Market Size Market Forecast 2029

Release Date: 15-Feb-2024

Global Bispecific Antibody Market Opportunity Insight 2029 Report Highlights:



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Bispecific antibodies (BsAbs) have emerged as a transformative force in cancer treatment during the last decade, presenting a novel strategy to harnessing the body’s immune system against cancer cells. Bispecific antibodies, which are based on the success of monoclonal antibodies, have a dual targeting mechanism, which has helped them acquire favor in oncology. Many bispecific antibodies have now hit the market, and many more intended to target specific protein combinations are in the works. The bispecific antibodies market has grown year after year and is likely to rise at an unprecedented rate in the next years.


As previously stated, bispecific antibodies stand out among immunotherapies because of their capacity to target two distinct antigens at the same time. This dual targeting mechanism improves the accuracy and specificity of immune responses, with the ability to overcome resistance mechanisms seen in some monospecific antibodies. Bispecific antibodies provide a more powerful and tailored attack on tumors by engaging both immune cells and cancer cells.


Several bispecific antibodies have been approved for use in cancer treatment, indicating important advances in the field. Blincyto (blinatumomab) and Rybrevant (amivantamab), approved for the treatment of acute lymphoblastic leukemia and non-small cell lung cancer, respectively, are notable examples. These antibodies have shown clinical efficacy, paving the path for the investigation of bispecific antibodies in numerous cancer types. Another example is Removab (catumaxomab), which, despite being removed from the market, is well known for being the first approved bispecific antibody.


Bispecific antibodies are being studied for hematological and solid tumors, as well as in combination with other therapy. Their capacity to activate many targets makes them potential candidates for a variety of malignancies. A plethora of current clinical trials defines the bispecific antibody landscape. AZD2936 and RO7247669, for example, are being tested for safety and efficacy in several cancer types. Another, Odronextamab, a CD20-directed T cell engager, is under review by the FDA and EMA.


Recognizing the promise of bispecific antibodies, pharmaceutical companies are actively involved in joint efforts to accelerate research and development as well as commercialization of bispecific antibodies. In the US, SystImmune and Bristol Myers Squibb recently collaborated to co-develop and co-commercialize BL-B01D1, a first-in-class EGFRxHER3 bispecific antibody.


Bispecific antibodies have enormous potential with promising future prospects, providing a robust and diverse treatment to activate the immune system against cancer cells. The benefits, ongoing trials, and collaborative efforts place bispecific antibodies as a dynamic force in defining the future of cancer therapies as the field evolves.


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