CD8+ Cell Expression Linked with Improved Survival Rate in Prostate Cancer

Release Date: 08-Nov-2020

In the past few years, many clinical studies have detected that high expression of CD8+ tumor infiltrating lymphocytes (TILs) is linked with improved overall survival rate in different types of cancers but the very prognostic role of TILs have remained unknown for many years now. Therefore, a group of researchers initiated a clinical study which was aimed towards evaluating the expression level of CD8+ TILs in case of prostate cancer patients who have undergone radical prostatectomy (RP).


A total of 230 patients having localized prostate cancers were selected for the study. The immune-technique that was used for doing the analyses was mmunohistochemistry. Also, computerized scoring system was used to study the density of the CD8+ cells in the patients. All the collected results were compared with low CD8+ TIL density groups. It was found that high CD8+ TILs were linked with improved overall survival rate, prostate cancer-specific survival andndash; 99% when compared with low CD8+ TIL density (95%). Therefore, it was concluded through the study that  cohort of patients with high CD8+ TIL density received higher 5-year biochemical recurrence-free survival and metastasis-free survival, thus leading towards the analysis that is important for developing further therapies.

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