Role Of Combination Therapy Strategies in Breast Cancer

Release Date: 16-Nov-2022

Early in the 20th century, chemotherapy was first used to treat cancer. This came about as a result of intensive study into the best treatments to either slowdown the growth of cancer tumors or, better yet, to eradicate them. When patients started showing resistance, health professionals and researchers were faced with a new challenge of crossing this hurdle and combination cancer therapy was developed. Combination therapy has been around for a while now and has established itself as a cornerstone of cancer treatment with positive outcomes. Combination cancer therapy has had a significant positive impact on patients with cancer, especially those with breast cancer, which has the highest prevalence rate among the general population.


A multimodal approach is used in the treatment of breast cancer, including neoadjuvant chemotherapy, surgery for operable tumors, radiation, adjuvant chemotherapy, and/or endocrine therapy. Breast cancer is treated with a variety of combination cancer therapy. Enhertu, an antibody-drug combination composed of the humanized monoclonal antibody trastuzumab covalently coupled to the topoisomerase I inhibitor deruxtecan, was recently approved by the FDA in August of 2022. Since Enhertu's application for HER2-low breast cancer was so ground-breaking, it was also given a fast track review even though it already held the breakthrough designation. In clinical trials, the drug was shown to increasing the survival rate of patients as compared to those on chemotherapy alone.


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The two-in-one injection PHESGO, developed by the Swiss multinational pharmaceutical corporation Roche, combines Herceptin and Perjeta, two of its best-selling medications. The cost of this new vaccine's treatment is anticipated to be at least 20% lower than the cost of giving the two medications separately, making it more affordable for patients. By drastically cutting down on their time spent in the clinic, it will also benefit patients with breast cancer and improve their quality of life. The vaccine has been hailed as a ground-breaking treatment for early and metastatic HER2-positive breast cancer because it is also first ever fixed dose formula in cancer treatment to combine two monoclonal antibodies. It is administered subcutaneously in conjunction with intravenous chemotherapy.


Roche, Merck, Daiichi Sankyo, AstraZeneca, Incyte, and Jiangsu HengRui are some of the major companies developing combination cancer medicines for breast cancer. All of them are now experimenting with other chemotherapy medication combinations, either alone or in conjunction with the two traditional cancer treatment techniques. More combination therapies for the treatment of breast cancer will be approved in the coming years, some possibly for less prevalent forms of the disease.


The long-term efficacy of various breast cancer drugs has fueled research in the field. Some of them are considered blockbusters due to their annual profits in the billions. The advancement of breast cancer research has also been aided by an increase in pharmaceutical company collaboration. Enhertu, for example, was developed collaboratively by AstraZeneca and Daiichi Sankyo. Their agreement also includes collaborative efforts to commercialize the drug.


Multiple types of combination therapies are currently being used in hospitals, clinics, and clinical trials. Several novel combinational approaches have emerged as a result of the need to improve patients' lives by overcoming the challenges of cancer management. As this method of treatment becomes more popular, technological advancements will almost certainly result in even more advanced strategies. Furthermore, as the biotechnology field advances, additional approaches including nanotechnology, computational analysis, and DNA sequencing technologies can be employed to improve various combination approaches in order to establish the most efficient treatment regimen for patients.





Neeraj Chawla

Kuick research

Research Head


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